The increased rates will apply to residential homemover and first-time buyer fixed rate mortgage deals from 30 July.
This will include homemover products, including new build, at 85-95% LTV and fixed for five years. These rates will go up by as much as 0.11%.
For first-time buyers, corresponding rates will be raised by as much as 0.12%.
Elsewhere, Santander will lower selected new business residential and buy-to-let (BTL) rates.
This includes its two-year fixed homemover mortgages, including new build, at 60-75% LTV. These will go down by up to 0.06% and rates will start at 3.73% with a £999 fee.
Episode 5: Larger Loans and Complex Lending: Powered by Partnership podcast from Newcastle for Intermediaries
Sponsored by Newcastle for Intermediaries
Selected residential remortgages at 60-85% LTV, fixed for two or five years, will be cut by up to 0.08%.
Further, all two-year fixed BTL remortgages at 60% LTV will be cut by 0.05%.
Across its product transfers, Santander will cut selected two- and five-year fixed rates at 60-85% LTV by up to 0.08% and all two-year fixed BTL options at 60% LTV by 0.05%.
Earlier this month, Santander introduced a change to allow borrowers to choose the start date of their new mortgage deal after a product transfer.