Giving Tuesday has taken place every year on 28 November since 2012 and encourages people to do good by volunteering, sharing skills or donating.
From 28 November, Giving Tuesday, until 1 December all 34 branches will be donation points for customers to donate clothes.
All clothing will be accepted provided it is in good condition, with donations of good quality menswear, womenswear and winter clothing will be especially welcomed.
Barnardo’s works with children, young people and their parents and carers to make sure that every child has the best start in life.
Amy Mason, ESG co-ordinator at the West Brom, said: “As a mutual, we’ve long been committed to giving back to our local communities to help create a fairer society, and so we’re really pleased to be celebrating this Giving Tuesday with our charity partner Barnardo’s.
“Whether it’s a full bag of clothing or just one t-shirt, the donations made via our branches will make a big difference to those who receive them.”
Hugh Sherriffe, Barnardo’s central regional director, said: “We would like to say a huge thank you to our partners at the West Brom for choosing to celebrate Giving Tuesday by giving back.
“Donations of good quality clothing will be gratefully received by our many retail stores in the West Midlands and will help us continue to bring positive change for children and young people across the UK.”