The lender is making the changes across a range of loan to values (LTV), including its highest residential LTV.
At 85 per cent LTV, the five-year fix with £999 fee has seen the biggest reduction by 20 basis points (bps) to 3.09 per cent – this is for purchases and remortgage.
At 60 per cent LTV a pair of purchase only deals also with £999 fee have been reduced – the two-year fix by three bps to 1.25 per cent and the five-year fix by two bps to 1.41 per cent.
Meanwhile, a trio of buy-to-let products for purchase and remortgage, all with £1,499 fee, have seen a range of rate cuts.
The two-year fix at 60 per cent LTV has been cut by 14 basis points to 1.4 per cent, and the five-year version is reduced by six basis points to 1.83 per cent.
A five-year fix at 75 per cent LTV has also been trimmed by four bps to 2.05 per cent
Finally, in its product transfer range, Santander has made a ten basis point to one 60 per cent LTV two-year fixed rate while all other rates have been maintained.
A Santander spokeswoman said: “We regularly review our products to manage the inflow of applications and are pleased to be able to offer customers a range of lower interest rates to help them towards their homeownership dreams.”